-January 2024:
- New paper published by our group
TFibroblast-derived extracellular vesicles as trackable efficient transporters of an experimental nanodrug with fibrotic heart and lung targeting.Theranostics. 2024 Jan 1;14(1):176-202. doi: 10.7150/thno.85409. eCollection 2024. eCollection 2024.-July 2023:
- New paper published by our group in collaboration with Maria Blasco´s group:
-January 2024:
- New paper published by our group
TFibroblast-derived extracellular vesicles as trackable efficient transporters of an experimental nanodrug with fibrotic heart and lung targeting.
Theranostics. 2024 Jan 1;14(1):176-202. doi: 10.7150/thno.85409. eCollection 2024. eCollection 2024.
-July 2023:
- New paper published by our group in collaboration with Maria Blasco´s group:
Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer.
Author information
-July 2022:
- New paper published by our group. Jorge Congrats for your paper. You are almost ready to defend your PhD.
Profibrotic Role of Inducible Heat Shock Protein 90α Isoform in Systemic Sclerosis.J Immunol. 2022 Jul 1;209(1):38-48. doi: 10.4049/jimmunol.2100430. Epub 2022 Jun 17.
-January 2022:
Epigenetic alterations of TGFβ and its main canonical signaling mediators in the context of cardiac fibrosis. Algeciras L, Palanca A, Maestro D, RuizdelRio J, Villar AV. J Mol Cell Cardiol. 2021 Oct;159:38-47. doi: 10.1016/j.yjmcc.2021.06.003.
-October 21:
Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein-nanomaterial hybrids.
Chemical Science.
DOI: 10.1039/D1SC04183E.
-July 2022:
- New paper published by our group. Jorge Congrats for your paper. You are almost ready to defend your PhD.
Profibrotic Role of Inducible Heat Shock Protein 90α Isoform in Systemic Sclerosis.
J Immunol. 2022 Jul 1;209(1):38-48. doi: 10.4049/jimmunol.2100430. Epub 2022 Jun 17.
-January 2022:
Epigenetic alterations of TGFβ and its main canonical signaling mediators in the context of cardiac fibrosis. Algeciras L, Palanca A, Maestro D, RuizdelRio J, Villar AV. J Mol Cell Cardiol. 2021 Oct;159:38-47. doi: 10.1016/j.yjmcc.2021.06.003.
J. Groen, A. Palanc, c, A. Aires , J.J. Conesa , D. Maestro, S. Rehbein, M. Harkiolakig, A. Villar
-June 2021.
Epigenetic alterations of TGFβ and its main canonical signaling mediators in the context of cardiac fibrosis
Journal of Molecular and Cellular Cardiology
Available online 10 June 2021
Available online 10 June 2021
-January 2021:
Chem. Science 2021. doi: doi:10.1039/d0sc05215a
https://pubs.rsc.org/en/content/articlelanding/2021/sc/d0sc05215a#!divAbstract
Engineering multifunctional metal/protein hybrid nanomaterials as tools for therapeutic intervention and high-sensitivity detection†
Ana R. Palanca, 
bc Elena Lopez-Martinez, a Kalotina Geraki, d Carlos Sanchez-Cano, *a Aitziber L. Cortajarena *af
bc Elena Lopez-Martinez, a Kalotina Geraki, d Carlos Sanchez-Cano, *a Aitziber L. Cortajarena *af -March 2020:
Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis.
Cells. 2020 Mar 30;9(4):833. doi: 10.3390/cells9040833.
-December 2019:
Russell AE, Sneider A, Witwer KW, Bergese P, Bhattacharyya SN, Cocks A, Cocucci E, Erdbrügger U, Falcon-Perez JM, Freeman DW, Gallagher TM, Hu S, Huang Y, Jay SM, Kano SI, Lavieu G, Leszczynska A, Llorente AM, Lu Q, Mahairaki V, Muth DC, Noren Hooten N, Ostrowski M, Prada I, Sahoo S, Schøyen TH, Sheng L, Tesch D, Van Niel G, Vandenbroucke RE, Verweij FJ, Villar AV, Wauben M, Wehman AM, Yin H, Carter DRF, Vader P.
J Extracell Vesicles. 2019 Nov 8;8(1):1684862. doi: 10.1080/20013078.2019.1684862
-October 2019:
1.-paper accepted in JEV in collaboration with the ISEV (International Society of Extracellular Vesicles). Title: "Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: An ISEV Position Paper arising from the ISEV Membranes and EVs Workshop"
2. Title: Reduction of cardiac TGFβ-mediated profibrotic events by inhibition of Hsp90 with engineered protein. Cáceres RA1, Chavez T1, Maestro D2, Palanca AR3, Bolado P2, Madrazo F4, Aires A5, Cortajarena AL6, Villar AV7. J Mol Cell Cardiol. 2018 Oct;123:75-87. doi: 10.1016/j.yjmcc.2018.08.016. Epub 2018 Sep 5.
3. Title: Extracellular heat shock protein 90 binding to TGFβ receptor I participates in TGFβ-mediated collagen production in myocardial fibroblasts. Author(s): García R, Merino D, Gómez JM, Nistal JF, Hurlé MA, Cortajarena AL, Villar AV. Cell Signal. 2016 Oct;28(10):1563-79. doi: 10.1016/j.cellsig.2016.07.003.
4. Title: microRNA-133: biomarker and mediator of cardiovascular diseases
Author(s): JF Nistal; AV Villar; R García; MA Hurlé
Biomarkers in Disease: Methods, Discoveries and Applications. Biomarkers in Cardiovascular Disease. DOI 10.1007/978-94-007-7741-5_28-1ISBN: 978-94-007-767, Springer Netherlands, Published:11/03/2016. Book chapter.
5. Title: p-SMAD2/3 and DICER promote
pre-miR-21 processing during pressure overload-associated myocardial remodeling
Author(s): Garcia, Raquel; Francisco Nistal, J.; Merino, David; Villar AV et al.
Source: Biochimica Et Biophysica Acta-Molecular Basis of Disease Volume: 1852 Issue: 7 Pages: 1520-1530 Published: JUL
2015
Times Cited: 0
DOI: 10.1016/j.bbadis.2015.04.006
6.Tittle: Metabolismo de los fármacos. Book:
Farmacología Humana 6ª edicción. Capítulo 5:72-82. Villar AV, del Arco C, Flórez J. 2014. Director Jesús Flórez. Editorial: Elsevier Masson. (ISBN de la edición impresa
978-84-458-2316-3)
7.Title: Bone morphogenetic protein 7
protects against pressure overload-induced left ventricular remodeling and
facilitates its regression in mice
Author(s): Merino, D.; Villar, A. V.; Nistal, J. F.; et al.
Source: Cardiovascular Research Volume: 103 Published: JUL
15 2014
Times Cited: 0
DOI: 10.1093/cvr/cvu098.49
8.Title: BAMBI (BMP and activin
membrane-bound inhibitor) protects the murine heart from pressure-overload
biomechanical stress by restraining TGF-beta signaling
Author(s): Villar, Ana V.; Garcia, Raquel; Llano, Miguel; et al.
Source: Biochimica Et Biophysica Acta-Molecular Basis of Disease Volume: 1832 Issue: 2 Pages: 323-335 Published: FEB
2013
Times Cited: 11
DOI: 10.1016/j.bbadis.2012.11.007
9. Title: Circulating Levels of miR-133a
Predict the Regression Potential of Left Ventricular Hypertrophy After Valve
Replacement Surgery in Patients With Aortic Stenosis
Author(s): Garcia, Raquel; Villar, Ana V.; Cobo, Manuel; et al.
Source: Journal of the American Heart Association Volume: 2 Issue: 4 Published: AUG
2013
Times Cited: 3
DOI: 10.1161/JAHA.113.000211
10. Title: Myocardial and circulating levels of
microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients
Author(s): Villar, Ana V.; Garcia, Raquel; Merino, David; et al.
Source: International Journal of Cardiology Volume: 167 Issue: 6 Pages: 2875-2881 Published: SEP
10 2013
Times Cited: 19
DOI: 10.1016/j.ijcard.2012.07.021
11. Title: TGF-beta Regulates Cytosolic Mir-21
Maturing in Mouse and Human Cardiac Fibroblasts Under Pressure Overload
Author(s): Garcia, Raquel; Villar, Ana V.; Hurle, Maria A.; et al.
Source: Circulation Volume: 128 Issue: 22 Published: NOV
26 2013
Times Cited: 0
12. Title: Activation by morphine withdrawal of
the hypothalamic-pituitary adrenal axis and heat shock protein 27 in the left
ventricle: role of extracellular signal-regulated kinase
Author(s): Villar, A. V.; Martinez-Laorden, E.; Almela, A.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S44 Published: MAR
15 2012
Times Cited: 0
13. Title: Androgens Contribute to Sex
Differences in Myocardial Remodeling under Pressure Overload by a Mechanism
Involving TGF-beta
Author(s): Montalvo, Cecilia; Villar, Ana V.; Merino, David; et al.
Source: Plos One Volume: 7 Issue: 4 Published: APR
25 2012
Times Cited: 8
DOI: 10.1371/journal.pone.0035635
14. Title: Chronic treatment with the opioid
antagonist naltrexone favours the coupling of spinal cord mu-opioid receptors
to G alpha(z) protein subunits
Author(s): Vadizan, Elsa M.; Diaz, Alvaro; Pilar-Cuellar, Fuencisla; et al.
Source: Neuropharmacology Volume: 62 Issue: 2 Pages: 757-764 Published: 2012
Times Cited: 0
DOI: 10.1016/j.neuropharm.2011.08.029
15. Title: Deletion of bambi abolishes the
protective effect of orchiectomy against pressure overload-induced myocardial
fibrosis by a mechanism involving b-catenin and androgen receptors
Author(s): Montalvo, C.; Villar, A. V.; Merino, D.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S96 Published: MAR
15 2012
Times Cited: 0
16. Title: The early myocardial response to
pressure overload in mice features synchronous and correlative over-expressions
of miR-21, miR-30c and collagens
Author(s): Garcia, R.; Merino, D.; Montalvo, C.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S87 Published: MAR 15 2012
Times Cited: 0
17. Title: Cardiac and Circulating Levels of
MicroRNA-21 Reflect Myocardial Fibrosis in Aortic Stenosis Patients
Author(s): Francisco Nistal, J.; Garcia, Raquel; Villar, Ana V.; et al.
Source: Circulation Volume: 124 Issue: 21 Published: 2011
Times Cited: 0
18. Title: CHRONIC TREATMENT WITH NALTREXONE
INDUCES NEUROCHEMICAL AND FUNCTIONAL SUPERSENSITIVITY TO SUFENTANIL BY
PROMOTING M-OPIOID RECEPTOR COUPLING TO GA(Z) PROTEINS
Author(s): Diaz, A.; Valdizan, E. M.; Pilar-Cuellar, F.; et al.
Source: Basic & Clinical Pharmacology & Toxicology Volume: 109 Pages: 42 Published: 2011
Times Cited: 0
19. Title: Circulating androgens contribute to
sex-related differences in myocardial remodeling under pressure overload
through a mechanism involving TGF-beta
Author(s): Montalvo, C.; Villar, A. V.; Merino, D.; et al.
Source: European Heart Journal Volume: 32 Pages: 1001 Published: 2011
Times Cited: 0
20. Title: Myocardial gene expression of
microRNA-133a and myosin heavy and light chains, in conjunction with clinical
parameters, predict regression of left ventricular hypertrophy after valve
replacement in patients with aortic stenosis
Author(s): Villar, Ana V.; Merino, David; Wenner, Mareike; et al.
Source: Heart Volume: 97 Issue: 14 Pages: 1132-1137 Published: 2011
Times Cited: 17
DOI: 10.1136/hrt.2010.220418
21. Title: Plasma Levels of MicroRNA-133a
Predict Complete Regression of Left Ventricular Hypertrophy After Valve
Replacement in Patients With Aortic Stenosis
Author(s): Francisco Nistal, J.; Garcia, Raquel; Villar, Ana V.; et al.
Source: Circulation Volume: 124 Issue: 21 Published: 2011
Times Cited: 0
21. Title: Sex differences in the expression of
antifibrotic microRNA-29b in the mouse heart under pressure overload
Author(s): Merino, D.; Garcia, R.; Garcia, N.; et al.
Source: European Heart Journal Volume: 32 Pages: 9-10 Published: 2011
Times Cited: 0
32. Title: Mutant mice lacking BAMBI (BMP and
Activin Membrane Bound Inhibitor) exhibit lusitropic dysfunction involving
altered beta 1 adrenergic signalling
Author(s): Villar, A. V.; Merino, D.; Ares, M.; et al.
Source: Cardiovascular Research Volume: 87 Pages: S78 Published: 2010
Times Cited: 0
24. Title: The cardiac hypertrophic phenotype
of BAMBI (BMP and Activin Membrane Bound Inhibitor) defective mice associates
increased myocardial expression of micro-RNA miR-21
Author(s): Villar, A. V.; Cobo, M.; Llano, M.; et al.
Source: Cardiovascular Research Volume: 87 Pages: S84 Published: 2010
Times Cited: 0
25. Title: Gender differences of
echocardiographic and gene expression patterns in human pressure overload left
ventricular hypertrophy
Author(s): Villar, Ana V.; Llano, Miguel; Cobo, Manuel; et al.
Source: Journal of Molecular and Cellular Cardiology Volume: 46 Issue: 4 Pages: 526-535 Published: APR 2009
Times Cited: 31
DOI: 10.1016/j.yjmcc.2008.12.024
26 Title: Left ventricular fibrosis secondary
to pressure overload is prevented in mice by neutralizing transforming growth
factor-beta
Author(s): Villar, A. V.; Cobo, M.; Llano, M.; et al.
Source: European Heart Journal Volume: 30 Pages: 221 Published: SEP 2009
Times Cited: 0
27. Title: Plasma Levels of Transforming Growth
Factor-beta 1 Reflect Left Ventricular Remodeling in Aortic Stenosis
Author(s): Villar, Ana V.; Cobo, Manuel; Llano, Miguel; et al.
Source: Plos One Volume: 4 Issue: 12 Published: 2009
Times Cited: 25
DOI: 10.1371/journal.pone.0008476
28 Title: Targeted deletion of BMP and Activin
Bound Inhibitor (BAMBI) increases and accelerates left ventricular remodeling
under pressure overload
Author(s): Llano, M.; Villar, A. V.; Cobo, M.; et al.
Source: European Heart Journal Volume: 30 Pages: 460 Published: SEP 2009
Times Cited: 0
29. Title: The Absence of the Physiological
Antagonist of Transforming Growth Factor-Beta, BAMBI, Promotes Alterations in
Myocardial Beta-1 Adrenergic Signaling
Author(s): Villar, Ana V.; Cuellar, Fuencisla; Valdizan, Elsa; et al.
Source: Circulation Volume: 120 Issue: 18 Pages: S721 Published: NOV 3 2009
Times Cited: 0
30. Title: EVOLUTION OF PRACTICAL TEACHING
METHODS IN PHARMACOLOGY IN THE MEDICAL SCHOOL OF THE UNIVERSITY OF CANTABRIA:
ADAPTATION TO NEW TECHNOLOGIES
Author(s): Villar, A. V.; Tramullas, M.; Martinez-Cue, C.; et al.
Source: Methods and Findings in Experimental and Clinical
Pharmacology Volume: 30 Pages: 183 Published: 2008
Times Cited: 0
31. Title: Gender Differences in
Echocardiographic and Gene Expression Patterns of Human Pressure Overload Left
Ventricular Hypertrophy
Author(s): Nistal, Francisco; Villar, Ana V.; Llano, Miguel; et al.
Source: Circulation Volume: 118 Issue: 18 Pages: S1035 Published: OCT 28 2008
Times Cited: 0
32. Title: INHIBITION OF TRANSFORMING GROWTH
FACTOR-beta S WITH NEUTRALIZING ANTIBODIES PREVENTS LEFT VENTRICULAR FIBROSIS
SECONDARY TO EXPERIMENTALLY INDUCED PRESSURE OVERLOAD
Author(s): Villar, A. V.; Tramullas, M.; Nistal, F.; et al.
Source: Methods and Findings in Experimental and Clinical
Pharmacology Volume: 30 Pages: 72 Published: 2008
Times Cited: 0
33. Title: Identification of a Novel Modulator
of Thyroid Hormone Receptor-Mediated Action
Author(s): Baumgartner, Bernhard G.; Orpinell, Meritxell; Duran, Jordi; et al.
Source: Plos One Volume: 2 Issue: 11 Published: NOV 21 2007
Times Cited: 17
DOI: 10.1371/journal.pone.0001183
34. Title: Modulation of PI-specific
phospholipase C by membrane curvature and molecular order
Author(s): Ahyayauch, H; Villar, AV; Alonso, A; et al.
Source: Biochemistry Volume: 44 Issue: 34 Pages: 11592-11600 Published: AUG 30 2005
Times Cited: 34
DOI: 10.1021/bi050715k
35. Title: Phosphorylation of
glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its
properties as a substrate for phospholipases
Author(s): Jones, DR; Paneda, C; Villar, AV; et al.
Source: Febs Letters Volume: 579 Issue: 1 Pages: 59-65 Published: JAN 3 2005
Times Cited: 5
DOI: 10.1016/j.febslet.2004.11.035
36. Title: Phosphatidylinositol hydrolysis by
PI-specific phospholipase C in lipidic vesicles. Effect of bilayer composition
and curvature.
Author(s): Goni, FM; Ahyayauch, H; Villar, AV; et al.
Source: Faseb Journal Volume: 18 Issue: 8 Pages: C179 Published: MAY
14 2004
Times Cited: 0
37. Title: Interaction of phospholipases C and
sphingomyelinase with liposomes
Author(s): Goni, FM; Villar, AV; Nieva, JL; et al.
Source: Liposomes, Pt B Volume: 372 Pages: 3-19 Published: 2003
Times Cited: 8
38. Title: Sphingomyelinase activity causes
transbilayer lipid translocation in model and cell membranes
Author(s): Contreras, FX; Villar, AV; Alonso, A; et al.
Source: Journal of Biological Chemistry Volume: 278 Issue: 39 Pages: 37169-37174 Published: SEP
26 2003
Times Cited: 78
DOI: 10.1074/jbc.M303206200
39. Title: Associations of B- and C-raf with
cholesterol, phosphatidylserine, and lipid second messengers - Preferential
binding of Raf to artificial lipid rafts
Author(s): Hekman, M; Hamm, H; Villar, AV; et al.
Source: Journal of Biological Chemistry Volume: 277 Issue: 27 Pages: 24090-24102 Published: JUL
5 2002
Times Cited: 60
DOI: 10.1074/jbc.M200576200
40. Title: Diacylglycerol effects on
phosphatidylinositol-specific phospholipase C activity and vesicle fusion
Author(s): Villar, AV; Goni, FM; Alonso, A
Source: Febs Letters Volume: 494 Issue: 1-2 Pages: 117-120 Published: APR
6 2001
Times Cited: 25
DOI: 10.1016/S0014-5793(01)02333-X
41. Title: Purification and characterization of
insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus
sativus) seeds
Author(s): Paneda, C; Villar, AV; Alonso, A; et al.
Source: Molecular Medicine Volume: 7 Issue: 7 Pages: 454-460 Published: JUL
2001
Times Cited: 6
42. Title: Leaky vesicle fusion induced by
phosphatidylinositol-specific phospholipase C: Observation of mixing of
vesicular inner monolayers
Author(s): Villar, AV; Alonso, A; Goni, FM
Source: Biochemistry Volume: 39 Issue: 46 Pages: 14012-14018 Published: NOV
21 2000
Times Cited: 40
DOI: 10.1021/bi992515c
43. Title: Towards the in vitro reconstitution
of caveolae. Asymmetric incorporation of glycosylphlosphatidylinositol (GPI)
and gangliosides into liposomal membranes
Author(s): Villar, AV; Alonso, A; Paneda, C; et al.
Source: Febs Letters Volume: 457 Issue: 1 Pages: 71-74 Published: AUG
20 1999
Times Cited: 12
DOI: 10.1016/S0014-5793(99)01010-8
44. Title: Phospholipase cleavage of
glycosylphosphatidylinositol reconstituted in liposomal membranes
Author(s): Villar, AV; Gona, FM; Alonso, A; et al.
Source: Febs Letters Volume: 432 Issue: 3 Pages: 150-154 Published: AUG
7 1998
Times Cited: 11
DOI: 10.1016/S0014-5793(98)00853-9
5. Title: p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling
Author(s): Garcia, Raquel; Francisco Nistal, J.; Merino, David; Villar AV et al.
Source: Biochimica Et Biophysica Acta-Molecular Basis of Disease Volume: 1852 Issue: 7 Pages: 1520-1530 Published: JUL 2015
Times Cited: 0
DOI: 10.1016/j.bbadis.2015.04.006
6.Tittle: Metabolismo de los fármacos. Book:
Farmacología Humana 6ª edicción. Capítulo 5:72-82. Villar AV, del Arco C, Flórez J. 2014. Director Jesús Flórez. Editorial: Elsevier Masson. (ISBN de la edición impresa
978-84-458-2316-3)
Author(s): Merino, D.; Villar, A. V.; Nistal, J. F.; et al.
Source: Cardiovascular Research Volume: 103 Published: JUL 15 2014
Times Cited: 0
DOI: 10.1093/cvr/cvu098.49
Author(s): Villar, Ana V.; Garcia, Raquel; Llano, Miguel; et al.
Source: Biochimica Et Biophysica Acta-Molecular Basis of Disease Volume: 1832 Issue: 2 Pages: 323-335 Published: FEB 2013
Times Cited: 11
DOI: 10.1016/j.bbadis.2012.11.007
Author(s): Garcia, Raquel; Villar, Ana V.; Cobo, Manuel; et al.
Source: Journal of the American Heart Association Volume: 2 Issue: 4 Published: AUG 2013
Times Cited: 3
DOI: 10.1161/JAHA.113.000211
Author(s): Villar, Ana V.; Garcia, Raquel; Merino, David; et al.
Source: International Journal of Cardiology Volume: 167 Issue: 6 Pages: 2875-2881 Published: SEP 10 2013
Times Cited: 19
DOI: 10.1016/j.ijcard.2012.07.021
Author(s): Garcia, Raquel; Villar, Ana V.; Hurle, Maria A.; et al.
Source: Circulation Volume: 128 Issue: 22 Published: NOV 26 2013
Times Cited: 0
Author(s): Villar, A. V.; Martinez-Laorden, E.; Almela, A.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S44 Published: MAR 15 2012
Times Cited: 0
Author(s): Montalvo, Cecilia; Villar, Ana V.; Merino, David; et al.
Source: Plos One Volume: 7 Issue: 4 Published: APR 25 2012
Times Cited: 8
DOI: 10.1371/journal.pone.0035635
14. Title: Chronic treatment with the opioid
antagonist naltrexone favours the coupling of spinal cord mu-opioid receptors
to G alpha(z) protein subunits
Author(s): Vadizan, Elsa M.; Diaz, Alvaro; Pilar-Cuellar, Fuencisla; et al.
Source: Neuropharmacology Volume: 62 Issue: 2 Pages: 757-764 Published: 2012
Times Cited: 0
DOI: 10.1016/j.neuropharm.2011.08.029
Author(s): Vadizan, Elsa M.; Diaz, Alvaro; Pilar-Cuellar, Fuencisla; et al.
Source: Neuropharmacology Volume: 62 Issue: 2 Pages: 757-764 Published: 2012
Times Cited: 0
DOI: 10.1016/j.neuropharm.2011.08.029
15. Title: Deletion of bambi abolishes the
protective effect of orchiectomy against pressure overload-induced myocardial
fibrosis by a mechanism involving b-catenin and androgen receptors
Author(s): Montalvo, C.; Villar, A. V.; Merino, D.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S96 Published: MAR 15 2012
Times Cited: 0
Author(s): Montalvo, C.; Villar, A. V.; Merino, D.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S96 Published: MAR 15 2012
Times Cited: 0
16. Title: The early myocardial response to
pressure overload in mice features synchronous and correlative over-expressions
of miR-21, miR-30c and collagens
Author(s): Garcia, R.; Merino, D.; Montalvo, C.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S87 Published: MAR 15 2012
Times Cited: 0
Author(s): Garcia, R.; Merino, D.; Montalvo, C.; et al.
Source: Cardiovascular Research Volume: 93 Pages: S87 Published: MAR 15 2012
Times Cited: 0
17. Title: Cardiac and Circulating Levels of
MicroRNA-21 Reflect Myocardial Fibrosis in Aortic Stenosis Patients
Author(s): Francisco Nistal, J.; Garcia, Raquel; Villar, Ana V.; et al.
Source: Circulation Volume: 124 Issue: 21 Published: 2011
Times Cited: 0
Author(s): Francisco Nistal, J.; Garcia, Raquel; Villar, Ana V.; et al.
Source: Circulation Volume: 124 Issue: 21 Published: 2011
Times Cited: 0
18. Title: CHRONIC TREATMENT WITH NALTREXONE
INDUCES NEUROCHEMICAL AND FUNCTIONAL SUPERSENSITIVITY TO SUFENTANIL BY
PROMOTING M-OPIOID RECEPTOR COUPLING TO GA(Z) PROTEINS
Author(s): Diaz, A.; Valdizan, E. M.; Pilar-Cuellar, F.; et al.
Source: Basic & Clinical Pharmacology & Toxicology Volume: 109 Pages: 42 Published: 2011
Times Cited: 0
Author(s): Diaz, A.; Valdizan, E. M.; Pilar-Cuellar, F.; et al.
Source: Basic & Clinical Pharmacology & Toxicology Volume: 109 Pages: 42 Published: 2011
Times Cited: 0
19. Title: Circulating androgens contribute to
sex-related differences in myocardial remodeling under pressure overload
through a mechanism involving TGF-beta
Author(s): Montalvo, C.; Villar, A. V.; Merino, D.; et al.
Source: European Heart Journal Volume: 32 Pages: 1001 Published: 2011
Times Cited: 0
Author(s): Montalvo, C.; Villar, A. V.; Merino, D.; et al.
Source: European Heart Journal Volume: 32 Pages: 1001 Published: 2011
Times Cited: 0
20. Title: Myocardial gene expression of
microRNA-133a and myosin heavy and light chains, in conjunction with clinical
parameters, predict regression of left ventricular hypertrophy after valve
replacement in patients with aortic stenosis
Author(s): Villar, Ana V.; Merino, David; Wenner, Mareike; et al.
Source: Heart Volume: 97 Issue: 14 Pages: 1132-1137 Published: 2011
Times Cited: 17
DOI: 10.1136/hrt.2010.220418
Author(s): Villar, Ana V.; Merino, David; Wenner, Mareike; et al.
Source: Heart Volume: 97 Issue: 14 Pages: 1132-1137 Published: 2011
Times Cited: 17
DOI: 10.1136/hrt.2010.220418
21. Title: Plasma Levels of MicroRNA-133a
Predict Complete Regression of Left Ventricular Hypertrophy After Valve
Replacement in Patients With Aortic Stenosis
Author(s): Francisco Nistal, J.; Garcia, Raquel; Villar, Ana V.; et al.
Source: Circulation Volume: 124 Issue: 21 Published: 2011
Times Cited: 0
Author(s): Francisco Nistal, J.; Garcia, Raquel; Villar, Ana V.; et al.
Source: Circulation Volume: 124 Issue: 21 Published: 2011
Times Cited: 0
21. Title: Sex differences in the expression of
antifibrotic microRNA-29b in the mouse heart under pressure overload
Author(s): Merino, D.; Garcia, R.; Garcia, N.; et al.
Source: European Heart Journal Volume: 32 Pages: 9-10 Published: 2011
Times Cited: 0
Author(s): Merino, D.; Garcia, R.; Garcia, N.; et al.
Source: European Heart Journal Volume: 32 Pages: 9-10 Published: 2011
Times Cited: 0
32. Title: Mutant mice lacking BAMBI (BMP and
Activin Membrane Bound Inhibitor) exhibit lusitropic dysfunction involving
altered beta 1 adrenergic signalling
Author(s): Villar, A. V.; Merino, D.; Ares, M.; et al.
Source: Cardiovascular Research Volume: 87 Pages: S78 Published: 2010
Times Cited: 0
Author(s): Villar, A. V.; Merino, D.; Ares, M.; et al.
Source: Cardiovascular Research Volume: 87 Pages: S78 Published: 2010
Times Cited: 0
24. Title: The cardiac hypertrophic phenotype
of BAMBI (BMP and Activin Membrane Bound Inhibitor) defective mice associates
increased myocardial expression of micro-RNA miR-21
Author(s): Villar, A. V.; Cobo, M.; Llano, M.; et al.
Source: Cardiovascular Research Volume: 87 Pages: S84 Published: 2010
Times Cited: 0
Author(s): Villar, A. V.; Cobo, M.; Llano, M.; et al.
Source: Cardiovascular Research Volume: 87 Pages: S84 Published: 2010
Times Cited: 0
25. Title: Gender differences of
echocardiographic and gene expression patterns in human pressure overload left
ventricular hypertrophy
Author(s): Villar, Ana V.; Llano, Miguel; Cobo, Manuel; et al.
Source: Journal of Molecular and Cellular Cardiology Volume: 46 Issue: 4 Pages: 526-535 Published: APR 2009
Times Cited: 31
DOI: 10.1016/j.yjmcc.2008.12.024
Author(s): Villar, Ana V.; Llano, Miguel; Cobo, Manuel; et al.
Source: Journal of Molecular and Cellular Cardiology Volume: 46 Issue: 4 Pages: 526-535 Published: APR 2009
Times Cited: 31
DOI: 10.1016/j.yjmcc.2008.12.024
26 Title: Left ventricular fibrosis secondary
to pressure overload is prevented in mice by neutralizing transforming growth
factor-beta
Author(s): Villar, A. V.; Cobo, M.; Llano, M.; et al.
Source: European Heart Journal Volume: 30 Pages: 221 Published: SEP 2009
Times Cited: 0
Author(s): Villar, A. V.; Cobo, M.; Llano, M.; et al.
Source: European Heart Journal Volume: 30 Pages: 221 Published: SEP 2009
Times Cited: 0
27. Title: Plasma Levels of Transforming Growth
Factor-beta 1 Reflect Left Ventricular Remodeling in Aortic Stenosis
Author(s): Villar, Ana V.; Cobo, Manuel; Llano, Miguel; et al.
Source: Plos One Volume: 4 Issue: 12 Published: 2009
Times Cited: 25
DOI: 10.1371/journal.pone.0008476
Author(s): Villar, Ana V.; Cobo, Manuel; Llano, Miguel; et al.
Source: Plos One Volume: 4 Issue: 12 Published: 2009
Times Cited: 25
DOI: 10.1371/journal.pone.0008476
28 Title: Targeted deletion of BMP and Activin
Bound Inhibitor (BAMBI) increases and accelerates left ventricular remodeling
under pressure overload
Author(s): Llano, M.; Villar, A. V.; Cobo, M.; et al.
Source: European Heart Journal Volume: 30 Pages: 460 Published: SEP 2009
Times Cited: 0
Author(s): Llano, M.; Villar, A. V.; Cobo, M.; et al.
Source: European Heart Journal Volume: 30 Pages: 460 Published: SEP 2009
Times Cited: 0
29. Title: The Absence of the Physiological
Antagonist of Transforming Growth Factor-Beta, BAMBI, Promotes Alterations in
Myocardial Beta-1 Adrenergic Signaling
Author(s): Villar, Ana V.; Cuellar, Fuencisla; Valdizan, Elsa; et al.
Source: Circulation Volume: 120 Issue: 18 Pages: S721 Published: NOV 3 2009
Times Cited: 0
Author(s): Villar, Ana V.; Cuellar, Fuencisla; Valdizan, Elsa; et al.
Source: Circulation Volume: 120 Issue: 18 Pages: S721 Published: NOV 3 2009
Times Cited: 0
30. Title: EVOLUTION OF PRACTICAL TEACHING
METHODS IN PHARMACOLOGY IN THE MEDICAL SCHOOL OF THE UNIVERSITY OF CANTABRIA:
ADAPTATION TO NEW TECHNOLOGIES
Author(s): Villar, A. V.; Tramullas, M.; Martinez-Cue, C.; et al.
Source: Methods and Findings in Experimental and Clinical Pharmacology Volume: 30 Pages: 183 Published: 2008
Times Cited: 0
Author(s): Villar, A. V.; Tramullas, M.; Martinez-Cue, C.; et al.
Source: Methods and Findings in Experimental and Clinical Pharmacology Volume: 30 Pages: 183 Published: 2008
Times Cited: 0
31. Title: Gender Differences in
Echocardiographic and Gene Expression Patterns of Human Pressure Overload Left
Ventricular Hypertrophy
Author(s): Nistal, Francisco; Villar, Ana V.; Llano, Miguel; et al.
Source: Circulation Volume: 118 Issue: 18 Pages: S1035 Published: OCT 28 2008
Times Cited: 0
Author(s): Nistal, Francisco; Villar, Ana V.; Llano, Miguel; et al.
Source: Circulation Volume: 118 Issue: 18 Pages: S1035 Published: OCT 28 2008
Times Cited: 0
32. Title: INHIBITION OF TRANSFORMING GROWTH
FACTOR-beta S WITH NEUTRALIZING ANTIBODIES PREVENTS LEFT VENTRICULAR FIBROSIS
SECONDARY TO EXPERIMENTALLY INDUCED PRESSURE OVERLOAD
Author(s): Villar, A. V.; Tramullas, M.; Nistal, F.; et al.
Source: Methods and Findings in Experimental and Clinical Pharmacology Volume: 30 Pages: 72 Published: 2008
Times Cited: 0
Author(s): Villar, A. V.; Tramullas, M.; Nistal, F.; et al.
Source: Methods and Findings in Experimental and Clinical Pharmacology Volume: 30 Pages: 72 Published: 2008
Times Cited: 0
33. Title: Identification of a Novel Modulator
of Thyroid Hormone Receptor-Mediated Action
Author(s): Baumgartner, Bernhard G.; Orpinell, Meritxell; Duran, Jordi; et al.
Source: Plos One Volume: 2 Issue: 11 Published: NOV 21 2007
Times Cited: 17
DOI: 10.1371/journal.pone.0001183
Author(s): Baumgartner, Bernhard G.; Orpinell, Meritxell; Duran, Jordi; et al.
Source: Plos One Volume: 2 Issue: 11 Published: NOV 21 2007
Times Cited: 17
DOI: 10.1371/journal.pone.0001183
34. Title: Modulation of PI-specific
phospholipase C by membrane curvature and molecular order
Author(s): Ahyayauch, H; Villar, AV; Alonso, A; et al.
Source: Biochemistry Volume: 44 Issue: 34 Pages: 11592-11600 Published: AUG 30 2005
Times Cited: 34
DOI: 10.1021/bi050715k
Author(s): Ahyayauch, H; Villar, AV; Alonso, A; et al.
Source: Biochemistry Volume: 44 Issue: 34 Pages: 11592-11600 Published: AUG 30 2005
Times Cited: 34
DOI: 10.1021/bi050715k
35. Title: Phosphorylation of
glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its
properties as a substrate for phospholipases
Author(s): Jones, DR; Paneda, C; Villar, AV; et al.
Source: Febs Letters Volume: 579 Issue: 1 Pages: 59-65 Published: JAN 3 2005
Times Cited: 5
DOI: 10.1016/j.febslet.2004.11.035
Author(s): Jones, DR; Paneda, C; Villar, AV; et al.
Source: Febs Letters Volume: 579 Issue: 1 Pages: 59-65 Published: JAN 3 2005
Times Cited: 5
DOI: 10.1016/j.febslet.2004.11.035
36. Title: Phosphatidylinositol hydrolysis by
PI-specific phospholipase C in lipidic vesicles. Effect of bilayer composition
and curvature.
Author(s): Goni, FM; Ahyayauch, H; Villar, AV; et al.
Source: Faseb Journal Volume: 18 Issue: 8 Pages: C179 Published: MAY 14 2004
Times Cited: 0
Author(s): Goni, FM; Ahyayauch, H; Villar, AV; et al.
Source: Faseb Journal Volume: 18 Issue: 8 Pages: C179 Published: MAY 14 2004
Times Cited: 0
37. Title: Interaction of phospholipases C and
sphingomyelinase with liposomes
Author(s): Goni, FM; Villar, AV; Nieva, JL; et al.
Source: Liposomes, Pt B Volume: 372 Pages: 3-19 Published: 2003
Times Cited: 8
Author(s): Goni, FM; Villar, AV; Nieva, JL; et al.
Source: Liposomes, Pt B Volume: 372 Pages: 3-19 Published: 2003
Times Cited: 8
38. Title: Sphingomyelinase activity causes
transbilayer lipid translocation in model and cell membranes
Author(s): Contreras, FX; Villar, AV; Alonso, A; et al.
Source: Journal of Biological Chemistry Volume: 278 Issue: 39 Pages: 37169-37174 Published: SEP 26 2003
Times Cited: 78
DOI: 10.1074/jbc.M303206200
Author(s): Contreras, FX; Villar, AV; Alonso, A; et al.
Source: Journal of Biological Chemistry Volume: 278 Issue: 39 Pages: 37169-37174 Published: SEP 26 2003
Times Cited: 78
DOI: 10.1074/jbc.M303206200
39. Title: Associations of B- and C-raf with
cholesterol, phosphatidylserine, and lipid second messengers - Preferential
binding of Raf to artificial lipid rafts
Author(s): Hekman, M; Hamm, H; Villar, AV; et al.
Source: Journal of Biological Chemistry Volume: 277 Issue: 27 Pages: 24090-24102 Published: JUL 5 2002
Times Cited: 60
DOI: 10.1074/jbc.M200576200
Author(s): Hekman, M; Hamm, H; Villar, AV; et al.
Source: Journal of Biological Chemistry Volume: 277 Issue: 27 Pages: 24090-24102 Published: JUL 5 2002
Times Cited: 60
DOI: 10.1074/jbc.M200576200
40. Title: Diacylglycerol effects on
phosphatidylinositol-specific phospholipase C activity and vesicle fusion
Author(s): Villar, AV; Goni, FM; Alonso, A
Source: Febs Letters Volume: 494 Issue: 1-2 Pages: 117-120 Published: APR 6 2001
Times Cited: 25
DOI: 10.1016/S0014-5793(01)02333-X
Author(s): Villar, AV; Goni, FM; Alonso, A
Source: Febs Letters Volume: 494 Issue: 1-2 Pages: 117-120 Published: APR 6 2001
Times Cited: 25
DOI: 10.1016/S0014-5793(01)02333-X
41. Title: Purification and characterization of
insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus
sativus) seeds
Author(s): Paneda, C; Villar, AV; Alonso, A; et al.
Source: Molecular Medicine Volume: 7 Issue: 7 Pages: 454-460 Published: JUL 2001
Times Cited: 6
Author(s): Paneda, C; Villar, AV; Alonso, A; et al.
Source: Molecular Medicine Volume: 7 Issue: 7 Pages: 454-460 Published: JUL 2001
Times Cited: 6
42. Title: Leaky vesicle fusion induced by
phosphatidylinositol-specific phospholipase C: Observation of mixing of
vesicular inner monolayers
Author(s): Villar, AV; Alonso, A; Goni, FM
Source: Biochemistry Volume: 39 Issue: 46 Pages: 14012-14018 Published: NOV 21 2000
Times Cited: 40
DOI: 10.1021/bi992515c
Author(s): Villar, AV; Alonso, A; Goni, FM
Source: Biochemistry Volume: 39 Issue: 46 Pages: 14012-14018 Published: NOV 21 2000
Times Cited: 40
DOI: 10.1021/bi992515c
43. Title: Towards the in vitro reconstitution
of caveolae. Asymmetric incorporation of glycosylphlosphatidylinositol (GPI)
and gangliosides into liposomal membranes
Author(s): Villar, AV; Alonso, A; Paneda, C; et al.
Source: Febs Letters Volume: 457 Issue: 1 Pages: 71-74 Published: AUG 20 1999
Times Cited: 12
DOI: 10.1016/S0014-5793(99)01010-8
Author(s): Villar, AV; Alonso, A; Paneda, C; et al.
Source: Febs Letters Volume: 457 Issue: 1 Pages: 71-74 Published: AUG 20 1999
Times Cited: 12
DOI: 10.1016/S0014-5793(99)01010-8
44. Title: Phospholipase cleavage of
glycosylphosphatidylinositol reconstituted in liposomal membranes
Author(s): Villar, AV; Gona, FM; Alonso, A; et al.
Source: Febs Letters Volume: 432 Issue: 3 Pages: 150-154 Published: AUG 7 1998
Times Cited: 11
DOI: 10.1016/S0014-5793(98)00853-9
Author(s): Villar, AV; Gona, FM; Alonso, A; et al.
Source: Febs Letters Volume: 432 Issue: 3 Pages: 150-154 Published: AUG 7 1998
Times Cited: 11
DOI: 10.1016/S0014-5793(98)00853-9